How can I best redesign the M&A framework when the client is the seller ?

Hi,

In traditional M&A cases (client is the acquirer) I usually split my analysis as below:

Financial

1 Benefits (A)Target Value Company (B) Synergies

2 Costs (A) Price paid, cost of financing (B) Integration costs

Non-Financial

1 Cultural and organizational fit

2 Regulatory fit

When the client is the seller, does the analysis determined by the choice of the owners to withdraw? For instance, if the owners leave the company, Should I only focus on the benefits (Value + Synergies) and regulatory fit as the rest is the concern of the acquirer? If the owners stay involved, Should I keep everything as all branches of the framework will be a topic of negotiation between the seller and the acquirer?

Thanks